Yes, you can use Telegram Signal Copier on a macOS if you use a VPS.
Basically, Telegram Signal Copier is a windows-based software. It works with all windows systems-32-bit and 64-bit. But it also works with other systems like macOS if you use a VPS.
VPS stands for Virtual Private Server. It is a computer running on the Internet, in the Cloud. It’s also very cheap starting from $10 a month.